Impact of tumour necrosis factor-α polymorphisms on irritant contact dermatitis.

摘要: Background. Genetic variations in genes coding for cytokines involved skin inflammation may alter their expression, thus changing the susceptibility to irritant contact dermatitis (ICD). Objectives. To determine prevalence of polymorphisms cytokine TNFA-238 and TNFA-308 patients with occupational ICD, compare it that controls. Methods. In a case–control study, 478 ICD hands were genotyped polymorphisms. The results compared those 393 apprentices from same high-risk occupations (controls). Results. For carrier variant TNFA-238A allele, odds ratio (OR) acquiring was 0.57 [95% confidence interval (CI) 0.34–0.97], suggesting protective effect A allele. genotype distributions 94.4% wild type (G/G), 5.6% heterozygous (G/A) 0% homozygous allele (A/A) patients, 90.9%, 8.5%, 0.6%, respectively controls. contrast, carriers TNFA-308A had an increased risk [OR 1.33; 95% CI 1.05–1.74; G/G 66.4%, G/A 31.2%, A/A 2.4% (patients) versus 73.5%, 24.6%, 1.9% controls]. Conclusions. Individuals polymorphism are less prone more develop hands, detrimental respectively.