IL-10 and TNFαGenotypes in SLE
作者： Patricia López , Carmen Gutiérrez , Ana Suárez
DOI: 10.1155/2010/838390
关键词: Autoantibody 、 Tumor necrosis factor alpha 、 Immune system 、 Interleukin 10 、 Cytokine 、 Genotype 、 Biology 、 Immunology 、 Pathogenesis 、 Promoter
摘要: The production of two regulators the inflammatory response, interleukin 10 (IL-10) and tumor necrosis factor (TNF), has been found to be deeply deregulated in SLE patients, suggesting that these cytokines may involved pathogenesis disease. Genetic polymorphisms at promoter regions IL-10 TNF genes have associated with different constitutive induced cytokine production. Given individual steady-state levels molecules deviate an initial immune response towards forms lymphocyte activation, functional genetic variants their promoters could influence development SLE. present review summarizes information previously reported about involvement on appearance, clinical phenotype, outcome. We show that, spite heterogeneity populations studied, existing knowledge points a relevant role genotypes
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