Role of Soluble ST2 as a Marker for Rejection after Heart Transplant.

摘要: BACKGROUND AND OBJECTIVES Endomyocardial biopsy is obligatory during the first year after heart transplant (HTx) for surveillance of acute rejection. Previous attempts using cardiac biomarkers detection rejection failed to show enough evidence substitute endomyocardial biopsy. Therefore, this study sought possibility soluble ST2 (sST2), a novel cardiovascular marker, as surrogate marker allograft HTx. SUBJECTS METHODS A total 494 blood samples acquired at time were analyzed in 67 HTx cases from September 2006 August 2014. Significant was defined International Society Heart and Lung Transplant (ISHLT) score ≥2R humoral accompanied by hemodynamic instability. RESULTS Twenty with 22 showed significant 4.0 (2.0-9.0) months The level sST2 positive correlation troponin I, N-terminal pro-B-type natriuretic peptide (all p<0.001), negative post-HTx (p<0.001). levels according ISHLT scores 36 (19-98), 28 (18-62), 15 (16-37), 191 (85-343) ng/mL, consecutively 0R, 1R, 2R, 3R+ (3R plus hemodynamically-unstable rejection) (p=0.003). However, when we studied within-subject effects mixed model, predefined point not different presence (p interaction=0.94). CONCLUSION Although known promising predictor events, its role patients predict seems be limited.