Usefulness of high-sensitivity troponin I for the monitoring of subclinical acute cellular rejection after cardiac transplantation.
作者： K.T. Ahn , J.-O. Choi , G.Y. Lee , H.-D. Park , E.-S. Jeon
DOI: 10.1016/J.TRANSPROCEED.2014.10.049
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摘要: Abstract Background There are conflicting data about the role of cardiac troponin I (cTnI) as determined by means conventional methods for prediction acute rejection after heart transplantation (HT). The purpose this study was to evaluate whether cTnI measured early prototype high-sensitivity assay (hs-cTnI) can predict episode HT compared with grade in endomyocardial biopsy (EMB). Methods This a single-center cross-sectional evaluating levels use both hs-cTnI and current less sensitive (conv-cTnI) assays at time EMB HT. We calculated an index ratio observed expected mean each individual patient defined measurements 60 days Results A total 252 biopsies from 47 patients were included study. In multivariable mixed model analysis relation presence HT, level significantly related ( P = .010). higher (median, 1.37; interquartile range [IQR], 1.23–2.88) those without 0.90; IQR, 0.51–1.16; Conclusions An increased episodes. Serial monitoring comparing it values might be useful detection
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