TopBP1 activates the ATR-ATRIP complex.
作者： Akiko Kumagai , Joon Lee , Hae Yong Yoo , William G. Dunphy
DOI: 10.1016/J.CELL.2005.12.041
关键词:
摘要: ATR is a key regulator of checkpoint responses to incompletely replicated and damaged DNA, but the mechanisms underlying control its kinase activity are unknown. TopBP1, vertebrate homolog yeast Cut5/Dbp11, has dual roles in initiation DNA replication regulation responses. We show that recombinant TopBP1 induces large increase both Xenopus human ATR. The ATR-activating domain resides conserved segment distinct from numerous BRCT repeats. isolated ectopic activation ATR-dependent signaling egg extracts cells. Furthermore, containing version with an inactivating point mutation defective regulation. These studies establish by crucial step processes.
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