Luteolin modulates expression of drug-metabolizing enzymes through the AhR and Nrf2 pathways in hepatic cells
作者： Tianshun Zhang , Yuki Kimura , Songyan Jiang , Kiyonari Harada , Yoko Yamashita
DOI: 10.1016/J.ABB.2014.05.023
关键词:
摘要: Abstract Drugs, xenobiotics including environmental pollutants, and certain food components modulate expression of drug-metabolizing enzymes. An aryl hydrocarbon receptor (AhR) possesses possible phase I II enzymes directly by binding its ligands such as 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD) indirectly regulating nuclear factor-erythroid-2-related factor 2 (Nrf2). Previous our result demonstrated that luteolin, a natural flavonoid existing in vegetables herbs, competed the TCDD to AhR. In present study, we investigated effect luteolin on through AhR Nrf2 pathways. Luteolin inhibited TCDD-induced protein enzyme cytochrome P450 1A1 (CYP1A1), NAD(P)H:quinone oxidoreductase-1 (NQO1) glutathione- S -transferase P1 (GSTP1) HepG2, Hepa1c1c7 RL-34 cells dose-dependent manner. suppressed TCDD- tert -butylhydroquinone-induced decreasing stability HepG2 cells. -butylhydroquinone treated cells, dose-dependently NQO1, GSTP1 aldo–keto reductases (AKRs). Of these, CYP1A1 was mainly dominated pathway, while NQO1 AKRs pathway. conclusion, inhibits modulating
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