Transcriptional regulation of the rat NAD(P)H:quinone reductase gene. Identification of regulatory elements controlling basal level expression and inducible expression by planar aromatic compounds and phenolic antioxidants.
作者： L V Favreau , C B Pickett
DOI: 10.1016/S0021-9258(20)64358-7
关键词:
摘要: We have identified two regions in the 5'-flanking sequence of rat quinone reductase gene that contain xenobiotic responsive elements. The DNA first region spans nucleotides -393 to -352 and shares identity with element (XRE) described for cytochrome P-450 CYPIA1 gene. second -434 -404 structural When a synthetic oligonucleotide corresponding was inserted front heterologous promoter linked chloramphenicol acetyltransferase gene, an increase basal level expression as well responsiveness beta-naphthoflavone t-butylhydroquinone, but not 2,3,7,8-tetrachlorodibenzo-p-dioxin, observed. sequence, -404, did any XRE shared large degree antioxidant recently glutathione S-transferase Ya subunit (Rushmore, T. H., King, R. G., Paulson, K. E., Pickett, C. B. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 3826-3830; Rushmore, J. Biol. Chem. 265, 14648-14653). These results indicate can be distinguished functionally from classical is also involved regulation by planar aromatic compounds phenolic antioxidants.
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