The thermodynamics of general and local anesthesia.

摘要: General anesthetics are known to cause depression of the freezing point transitions in biomembranes. This is a consequence ideal mixing anesthetic drugs membrane fluid phase and exclusion from solid phase. Such generic law provides physical justification famous Meyer-Overton rule. We show here that general anesthetics, barbiturates, local all display same effect on melting transitions. Their reversed by hydrostatic pressure. Thus, thermodynamic behavior very similar anesthetics. present detailed analysis heat capacity profiles membranes presence Using this analysis, we able describe experimentally observed calorimetric predict features arbitrary molecules. In addition, discuss origin cutoff long-chain alcohols additivity