A stable, oligosymptomatic malaria focus in Thailand.

摘要: Blood from most of the 250 residents a non-migratory farming village in south-eastern Thailand was visually examined for malaria parasites monthly 2 years. Nearly 97% population had at least one (median = 5) patent Plasmodium falciparum infection per year; 72% due to P. vivax 1). This contrasted with slide positivity rate 17% calculated 12 months passive case detection before study began. Children 1-9 years old highest mean prevalence (51%) and geometric density (10/500 white blood cells) falciparum. Fewer than half expected number mixed infections were found but these more common high densities Individuals over 19 comprised 52% accounted only 18% 32% gametocytaemias. Fever rates marginally higher those below 10 (8%) occurred equal frequency or negative. The spleen (89% stage 1) 24% under 15 7% older. No mortality seen cases treated d quinine+tetracycline (QT) cleared as often given dose mefloquine+sulfadoxine+pyrimethamine (MSP); both treatments reduced not cured. Apparently unsupervised compliance no better MSP QT. role played by hyperendemic, cryptic foci Asian epidemics may have been underestimated.