Metabolism of N8‐Monoacetylspermidine in Rat Hepatoma Cells

摘要: Recent evidence has indicated a role for the acetyl derivatives of polyamines, particularly N8-monoacetylspermidine, as activators l-ornithine decarboxylase in rat hepatoma tissue culture (HTC) cells. This is contrast with well-described negative regulatory control ornithine exerted by their non-acetylated counterparts. Because possibility rapid extracellular and intracellular catabolism metabolism N8-monoacetylspermidine its effect on HTC cell have been investigated, under conditions which eliminate catabolism. Differing from previous reports, we demonstrate that does not elevate activity when added at low concentrations to medium Higher decrease dose-dependent manner. cannot be unambiguously attributed derivative itself, because presence situ very active deacetylase, generates spermidine intracellularly.