N8-acetyl spermidine protects rat cerebellar granule cells from low K+-induced apoptosis.

摘要: The endogenous polyamines have been extensively studied with respect to their role in cellular death mechanisms, although the results are contradictory. In contrast, primary metabolites, N-acetyl polyamines, not much studied. It has hypothesized that metabolites may play a and some of variability between different reports be due altered polyamine metabolic capacities. Using cultures rat cerebellar granule cells, effects examined on basal, cytosine β-D-arabinofuranoside (Ara-C)-induced low K+-induced apoptosis. None compounds affected either basal or Ara-C-induced apoptosis at doses. At higher doses, all were toxic. Two compounds, N8-acetyl spermidine N1-acetyl spermine, found protect cells from apoptosis, which shown p53-independent. parent devoid protective activity subtoxic This represents first time an anti-apoptotic effect demonstrated. These raise possibility these act as neuroprotectants. lack provides evidence least two forms p53-independent can regulated independently. J. Neurosci. Res. 55:341–351, 1999.  © 1999 Wiley-Liss, Inc.