Papillomavirus E1 proteins: form, function, and features.
作者： Van G. Wilson , Michael West , Kelly Woytek , Dandapani Rangasamy
关键词:
摘要: The E1 proteins are the essential origin recognition for papillomavirus (PV) replication. bind to specific DNA elements in viral of replication and assemble into hexameric helicases with aid a second protein, E2. resultant helicase complex initiates unwinding provide template subsequent syntheses progeny DNA. In addition ATP-dependent activity, interact recruit several host cell origin, including polymerase α RPA. This review will compare basic structures features human (HPV) bovine (BPV1) papillomaviruses an emphasis on mechanisms function.
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