Membrane lipids in invadopodia and podosomes: Key structures for cancer invasion and metastasis

摘要: Invadopodia are extracellular matrix (ECM)-degrading protrusions formed by invasive cancer cells. Podosomes structures functionally similar to invadopodia that found in oncogene-transformed fibroblasts and monocyte-derived cells, including macrophages osteoclasts. These thought play important roles the pericellular remodeling of ECM during invasion metastasis. Much effort has been directed toward identification molecular components regulators invadopodia/podosomes, which could be therapeutic targets treatment malignant cancers. However, it remains largely unknown how these assembled into invadopodia/podosomes assembly process is spatially temporally regulated. This review will summarize recent progress on mechanisms invadopodia/podosome formation, with strong emphasis lipid rafts phosphoinositides.