68Ga-DOTATOC PET/CT and somatostatin receptor (sst1-sst5) expression in normal human tissue: correlation of sst2 mRNA and SUVmax

摘要: By targeting somatostatin receptors (sst) radiopeptides have been established for both diagnosis and therapy. For physiologically normal human tissues the study provides a normative database of maximum standardized uptake value (SUVmax) sst mRNA. A total 120 patients were subjected to diagnostic 68Ga-DOTATOC positron emission tomography (PET)/CT (age range 19–83 years). SUVmax values measured in defined by morphology, absence surgical intervention metastatic spread during clinical follow-up. Expression subtypes (sst1–sst5) was independently pooled adult tissue real-time reverse transcriptase polymerase chain reaction (RT-PCR). revealed region-specific pattern (e.g., mean ± SD, spleen 31.1 ± 10.9, kidney 16.9 ± 5.3, liver 12.8 ± 3.6, stomach 7.0 ± 3.1, head pancreas 6.2 ± 2.3, small bowel 4.8 ± 1.8, thyroid 4.7 ± 2.2, bone 3.9 ± 1.3, large 2.9 ± 0.8, muscle 2.1 ± 0.5, parotid gland 1.9 ± 0.6, axillary lymph node 0.8 ± 0.3 lung 0.7 ± 0.3). age independent. Gender differences evident within (female/male: 3.7 ± 1.6/5.5 ± 2.4, p < 0.001; Mann-Whitney U test) pancreatic (5.5 ± 1.9/6.9 ± 2.2, p < 0.001). The mRNA widely expressed heterogeneous, showing sst1 be most abundant. exclusively correlated with sst2 expression (r = 0.846, Spearman rank correlation analysis), whereas there no other four subtypes. In imaging has related at level novel may improve diagnostics, monitoring therapy sst-expressing tumours or inflammation on molecular basis.