Boronic acid-containing optically active microspheres: Preparation, chiral adsorption and chirally controlled release towards drug DOPA

摘要: A judicious combination of chiral structure with other functionalities in one entity may provide novel materials. For this purpose, boronic acid functional group was integrated optically active helical substituted polyacetylene microspheres. To prepare the designed microspheres, two acetylene monomers, i.e. monomer M1 and achiral M2 which prepared from a derivative, were synthesized copolymerized through suspension polymerization for constructing polymeric SEM images demonstrated successful formation X-ray photoelectron spectroscopy measured to determine content on surface as-prepared Circular dichroism spectra showed that one-handed helices formed copolymer chains enabled microspheres exhibit enantio-differentiating adsorption capacity towards 3,4-dihydroxy-l-phenylalanine (l-DOPA), whereas 3,4-dihydroxy-d-phenylalanine (d-DOPA) preferentially released. Amazing synergistic effects occurred polymer pendant moieties. Desorption recyclability also clearly verified. The unprecedented hold practical applications developing materials used adsorption, enantiomeric drug controlled release, etc.