Extrasynaptic GABAA receptors in rat pontine reticular formation increase wakefulness.
作者： Giancarlo Vanini , Helen A. Baghdoyan
DOI: 10.5665/SLEEP.2444
关键词:
摘要: Study objectives Gamma-aminobutyric acid (GABA) causes phasic inhibition via synaptic GABAA receptors and tonic extrasynaptic receptors. GABA levels in the extracellular space regulate arousal state cognition by volume transmission GABAergic pontine reticular formation promotes wakefulness. No previous studies have determined whether an agonist at administered into alters sleep Therefore, this study used gaboxadol (THIP; that contain a δ subunit) to test hypothesis within modulate Design Within/between subjects. Setting University of Michigan. Patients or participants Adult male Crl:CD*(SD) (Sprague-Dawley) rats (n = 10). Interventions Microinjection gaboxadol, nonsubtype selective receptor muscimol (positive control), saline (negative control) rostral formation. Measurements results Gaboxadol significantly increased wakefulness decreased both nonrapid eye movement rapid concentration-dependent manner. Relative saline, did not alter electroencephalogram power. same received sleep. Conclusion Tonic subunit may be one mechanism which pool endogenous Citation Vanini G; Baghdoyan HA. Extrasynaptic rat increase SLEEP 2013;36(3):337-343.
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