Itraconazole to prevent fungal infections in chronic granulomatous disease.

摘要: Background Chronic granulomatous disease is a rare disorder in which the phagocytes fail to produce hydrogen peroxide. The patients are predisposed bacterial and fungal infections. Prophylactic antibiotics interferon gamma have reduced infections, but there also danger of life-threatening We assessed efficacy itraconazole as prophylaxis against serious infections chronic disease. Methods Thirty-nine at least 5 years old (6 female 33 male; mean age, 14.9 years) were enrolled randomized, double-blind, placebo-controlled study. After initially assigned treatment, each patient alternated between placebo annually. Patients 13 age or older all weighing 50 kg received single dose 200 mg per day; those less than 100 day. primary end point was severe infection, dete...