Coumarin’s Anti-Quorum Sensing Activity Can Be Enhanced When Combined with Other Plant-Derived Small Molecules

摘要: Coumarins are class of natural aromatic compounds based on benzopyrones (2H-1-benzopyran-2-ones). They identified as secondary metabolites in about 150 different plant species. The ability coumarins to inhibit cell-to-cell communication bacterial communities (quorum sensing; QS) has been previously described. Coumarin and its derivatives extracts often found together with other small molecules that show anti-QS properties too. aim this study was find the most effective combinations plant-derived various plants QS Chromobacterium violaceum ATCC 31532 violacein production bioassay. coumarin derivatives: 7-hydroxycoumarin, 7.8-dihydroxy-4-methylcoumarin, were included study. Combinations gamma-octalactone, 4-hexyl-1.3-benzenediol, 3.4.5-trimethoxyphenol vanillin, oak bark (Quercus cortex), eucalyptus leaves (Eucalyptus viminalis) extracts, analyzed a When testing two-component compositions, it shown 4-hexyl-1.3-benzendiol, gamma-octalactone showed supra-additive effect. all three resulted three- five-fold reduction concentration each compound needed achieve EC50 (half maximal concentration) against C. 31532.