The regulation of myosin II in Dictyostelium.

摘要: Dictyostelium conventional myosin (myosin II) is an abundant protein that plays a role in various cellular processes such as cytokinesis, cell protrusion and development. This review will focus on the signal transduction pathways regulate II during movement. Myosin appears to have two modes of action Dictyostelium: local stabilization cytoskeleton by filament association actin meshwork (structural mode) force generation contraction filaments (motor mode). Some processes, movement under restrictive environment, require only structural mode myosin. However, cytokinesis suspension uropod retraction depend motor activity well. can self-assemble into bipolar filaments. The formation these negatively regulated heavy chain phosphorylation through set novel alpha kinases relatively well understood. recently it has become clear their translocation cortex are separate events. Translocation depends filamentous actin, cGMP pathway possibly also cAMP phosphodiesterase RegA p21-activated kinase PAKa. regulatory light A. Unlike kinases, this enzyme not calcium but activated cGMP-induced via upstream subsequent autophosphorylation.