dTyr-D-Phe3 (Pro-D-Phe-Pro-Gly) interacts specifically with amygdaloid-kindled seizures and is capable of preventing the learning deficit occurring after kindling.
作者： Axel Becker , Gisela Grecksch
DOI: 10.1016/0196-9781(92)90142-P
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摘要: Abstract In amygdala-kindled rats a deficit in learning brightness discrimination was found. We concluded that this result provides reliable basis for creating an animal model of cognitive dysfunctions epileptics. Recently, des-tyrosine D-amino acid substituted derivative bovine β-casein (1–5) reported to exhibit anticonvulsant as well antidepressant activity. Therefore, we tested the effect peptide on kindled seizures and after kindling. It found suppressed duration whereas seizure severity not influenced. Futhermore, performance peptide-treated significantly higher than controls.
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