Characterization of alkaloids in Sophora flavescens Ait. by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry.
作者： Guoqiang Liu , Jing Dong , Hong Wang , Yuki Hashi , Shizhong Chen
DOI: 10.1016/J.JPBA.2010.12.024
关键词:
摘要: Sophora flavescens Ait., a well-known Chinese herbal medicine, is widely used in clinical practice for the treatment of viral hepatitis, cancer, gastrointestinal hemorrhage, and skin diseases. This paper first report on method based combined use high-performance liquid chromatography, photodiode array detection, electrospray ionization tandem mass spectrometry comprehensive systematic separation characterization bioactive alkaloids Ait. A total 22 constituents were identified basis extracted ion chromatograms different [M+H](+) ions present S. Among these, 5 unambiguously by comparing experimental data their retention times MS(n) spectra with those authentic compounds, 17 other tentatively fragmentation behaviors and/or molecular weight information from literatures. Furthermore, some characteristic pathways detected examined. may be useful characterizing possible applications formulations.
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sci-hub.se 参考文章(21)
Hang TaiJun, Song Min, Zhao Hua, HPLC fingerprint of alkaloid components of Sophora flavescens Ait. Journal of China Pharmaceutical University. ,vol. 40, pp. 139- 143 ,(2009)
Guan Ye, Hai-Yan Zhu, Zhi-Xiong Li, Chun-Hui Ma, Ming-Song Fan, Zhao-Lin Sun, Cheng-Gang Huang, LC-MS characterization of efficacy substances in serum of experimental animals treated withSophora flavescens extracts Biomedical Chromatography. ,vol. 21, pp. 655- 660 ,(2007) , 10.1002/BMC.805
Xiu-Jin Liu, Mei-Ai Cao, Wen-Hai Li, Cheng-Shuo Shen, Shi-Qiang Yan, Cheng-Shan Yuan, Alkaloids from Sophora flavescens Aition Fitoterapia. ,vol. 81, pp. 524- 527 ,(2010) , 10.1016/J.FITOTE.2010.01.008
Jianyuan Yin, Yuanhong Xu, Jing Li, Erkang Wang, Analysis of quinolizidine alkaloids in Sophora flavescens Ait. by capillary electrophoresis with tris(2,2 '-bipyridyl) ruthenium (II)-based electrochemiluminescence detection Talanta. ,vol. 75, pp. 38- 42 ,(2008) , 10.1016/J.TALANTA.2007.10.003
Changqing Yi, Xi Chen, Xiaoqing Yang, Xiaoru Wang, Liquid chromatography of active principles in Sophora flavescens root. Journal of Chromatography B. ,vol. 812, pp. 149- 163 ,(2004) , 10.1016/J.JCHROMB.2004.08.032
Yufeng Zhang, Peng Zhang, Yiyu Cheng, Structural characterization of isoprenylated flavonoids from Kushen by electrospray ionization multistage tandem mass spectrometry Journal of Mass Spectrometry. ,vol. 43, pp. 1421- 1431 ,(2008) , 10.1002/JMS.1423
Bo Ding, Tingting Zhou, Guorong Fan, Zhanying Hong, Yutian Wu, Qualitative and quantitative determination of ten alkaloids in traditional Chinese medicine Corydalis yanhusuo W.T. Wang by LC-MS/MS and LC-DAD. Journal of Pharmaceutical and Biomedical Analysis. ,vol. 45, pp. 219- 226 ,(2007) , 10.1016/J.JPBA.2007.06.009
Lei Zhang, Liang Xu, Shan-Shan Xiao, Qiong-Feng Liao, Qing Li, Jian Liang, Xiao-Hui Chen, Kai-Shun Bi, Characterization of flavonoids in the extract of Sophora flavescens Ait. by high-performance liquid chromatography coupled with diode-array detector and electrospray ionization mass spectrometry Journal of Pharmaceutical and Biomedical Analysis. ,vol. 44, pp. 1019- 1028 ,(2007) , 10.1016/J.JPBA.2007.04.019
Yuhong Zhou, Hongli Shan, Guofen Qiao, Xiaohong Sui, Yanjie Lu, Baofen Yang, Inotropic effects and mechanisms of matrine, a main alkaloid from Sophora flavescens AIT. Biological & Pharmaceutical Bulletin. ,vol. 31, pp. 2057- 2062 ,(2008) , 10.1248/BPB.31.2057
Lingdi Ma, Shihong Wen, Yan Zhan, Yujuan He, Xiaoshan Liu, Jikai Jiang, Anticancer Effects of the Chinese Medicine Matrine on Murine Hepatocellular Carcinoma Cells Planta Medica. ,vol. 74, pp. 245- 251 ,(2008) , 10.1055/S-2008-1034304