Acute effects of styrene inhalation on the neuroendocrinological system of rats and the different effects in male and female rats.

摘要: There have been several epidemiological and experimental studies about styrene from the neuroendocrinological viewpoint. Some reported that exposure affected system enhanced prolactin (PRL) secretion, but others denied those effects. It was assumed caused depletion of dopamine (DA), which is a PRL inhibitor, that, in consequence, level increased. However, not only DA also many other factors control secretion. Therefore, mechanism hypersecretion has yet clearly elucidated. In addition, effects on female reproductive reported, susceptibility needs to be further studied. investigate what causes how different males females, we studied acute male rats. Immediately after 150 ppm vapor for 10 days (8 h/day), rats were killed, blood brain samples collected. The concentration blood, hormones such as PRL, growth hormone (GH) thyroid-stimulating (TSH) plasma neurotransmitters various regions measured. higher than rats, significantly increased exposed compared with controls. No significant change observed We did observe any changes DA, 5-hydroxytryptamine (5-HT) or their metabolites. Because either enhancing secretion remains unclear. These results suggest may cause sensitivity male.