Anti-biofilm agents: recent breakthrough against multi-drug resistant Staphylococcus aureus.

摘要: Staphylococcus aureus is a Gram-positive pathogen that causes potentially life-threatening nosocomial- and community-acquired infections, such as osteomyelitis endocarditis. has the ability to form multicellular, surface-adherent communities called biofilms, which enables it survive in various sources of stress, including antibiotics, nutrient limitations, heat shock, immune responses. Biofilm-forming capacity now recognized an important virulence determinant development staphylococcal device-related infections. In light projected increase numbers elderly patients who will require semi-permanent indwelling medical devices artificial knees hips, we can anticipate expanded need for new agents treatment options manage biofilm-associated infections expanding at-risk population. With better understanding biofilm formation growth, novel strategies target caused by S. have recently been described seem promising future anti-biofilm therapies.