Silver oxide-containing hydroxyapatite coating has in vivo antibacterial activity in the rat tibia.

摘要: Bacterial infection is a serious postoperative complication of joint replacement. To prevent infections related to implantation, we have developed novel antibacterial coating with Ag-containing hydroxyapatite (Ag-HA). In the present study, examined activity Ag-HA implant coatings in medullary cavity rat tibiae. Forty 10-week-old rats received implantation Ag-HA- or HA-coated titanium rods, then were inoculated ∼1.0 × 102 colony-forming units methicillin-resistant Staphylococcus aureus. counts calculated for euthanized at 24, 48, and 72 h postoperatively. Serum levels Ag (in group only) 4 weeks. Radiographic evaluations bone also performed Tibiae from both groups showing evaluated histologically. Significant differences bacterial seen 72 h. Mean concentrations serum peaked about 48 h after gradually decreased. radiographic scores significantly lower implants than HA implants. Histological examination showed better results abscesses, resorption, destruction cortical around Ag-HA-coated These indicate that may help surgical-site associated © 2013 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 31:1195–1200,