Effects of breviscapine on pulmonary inflammatory response and lung injury in children undergoing open heart surgery.
作者： Jun Chen , Ying-Hua Zhao , Xiu-Lan Liu , Xiao-Ling Chen , Jun Li
DOI: 10.1080/10286020.2011.652952
关键词:
摘要: This study examined the effects of breviscapine (1) on pulmonary inflammatory response and lung function in pediatric patients undergoing open heart surgery. Forty-five children (ASA II or III, aged 2–72 months) were randomly assigned to control group (saline, Group C), low dose 1 (0.5 mg/kg, Bre0.5), high (1.0 mg/kg, Bre1.0), 15 cases each group. Plasma concentrations procalcitonin (PCT) neutrophil elastase (NE) measured compared at different time points. PCT NE increased after cardiopulmonary bypass (CPB) induction, lower 1-treated groups. The present results indicated that continuous infusion before CPB suppressed production attenuated systemic response, which could result protective effect
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