摘要: Summary The LDL receptor's structure and function at the cellular level has been well characterized mostly by work of Goldstein, Brown, co-workers. A large number mutations receptor gene reported worldwide their clinical relevance to severity familial hypercholesterolemia evaluated. There is ample evidence that does not mediate clearence only; it also involved in clearance triglyceride-rich lipoproteins including postprandial lipoproteins. Several nutrients, drugs, hormones modulate receptor, through different mechanisms. Exciting new information regarding identification other members family evolving. role its processes beyond lipoprotein emerging.
sci-hub.se 参考文章(60)
R Charles Scriver, The Metabolic and Molecular Bases of Inherited Disease ,(1995)
M. Mulder, P. Lombardi, H. Jansen, T.J. van Berkel, R.R. Frants, L.M. Havekes, Low Density Lipoprotein Receptor Internalizes Low Density and Very Low Density Lipoproteins That Are Bound to Heparan Sulfate Proteoglycans via Lipoprotein Lipase Journal of Biological Chemistry. ,vol. 268, pp. 9369- 9375 ,(1993) , 10.1016/S0021-9258(18)98359-6
H.Y. Hsu, A.C. Nicholson, D.P. Hajjar, Basic fibroblast growth factor-induced low density lipoprotein receptor transcription and surface expression. Signal transduction pathways mediated by the bFGF receptor tyrosine kinase. Journal of Biological Chemistry. ,vol. 269, pp. 9213- 9220 ,(1994) , 10.1016/S0021-9258(17)37096-5
J.M. Wilson, In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses. Journal of Biological Chemistry. ,vol. 269, pp. 13695- 13702 ,(1994) , 10.1016/S0021-9258(17)36886-2
Henry J. Pownall, Martha P. Mims, Asha T. Darnule, Louis C. Smith, James T. Sparrow, Reuben W. Tovar, David P. Via, Doris A. Sparrow, A nonexchangeable apolipoprotein E peptide that mediates binding to the low density lipoprotein receptor. Journal of Biological Chemistry. ,vol. 269, pp. 20539- 20547 ,(1994) , 10.1016/S0021-9258(17)32027-6
X. Wang, M.R. Briggs, X. Hua, C. Yokoyama, J.L. Goldstein, M.S. Brown, Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization. Journal of Biological Chemistry. ,vol. 268, pp. 14497- 14504 ,(1993) , 10.1016/S0021-9258(19)85266-3
K.J. Williams, G.M. Fless, K.A. Petrie, M.L. Snyder, R.W. Brocia, T.L. Swenson, Mechanisms by which lipoprotein lipase alters cellular metabolism of lipoprotein(a), low density lipoprotein, and nascent lipoproteins. Roles for low density lipoprotein receptors and heparan sulfate proteoglycans. Journal of Biological Chemistry. ,vol. 267, pp. 13284- 13292 ,(1992) , 10.1016/S0021-9258(18)42208-9
Jingwen Liu, R. I. Grove, R. E. Vestal, Oncostatin M activates low density lipoprotein receptor gene transcription in sterol-repressed liver cells Cell Growth & Differentiation. ,vol. 5, pp. 1333- 1338 ,(1994)
S Bertolini, D D Patel, D A Coviello, N Lelli, M Ghisellini, R Tiozzo, P Masturzo, N Elicio, B L Knight, S Calandra, PARTIAL DUPLICATION OF THE EGF PRECURSOR HOMOLOGY DOMAIN OF THE LDL-RECEPTOR PROTEIN CAUSING FAMILIAL HYPERCHOLESTEROLEMIA (FH-SALERNO) Journal of Lipid Research. ,vol. 35, pp. 1422- 1430 ,(1994) , 10.1016/S0022-2275(20)40083-5
Dudley K. Strickland, Maria Z. Kounnas, W. Scott Argraves, LDL receptor-related protein: a multiligand receptor for lipoprotein and proteinase catabolism. The FASEB Journal. ,vol. 9, pp. 890- 898 ,(1995) , 10.1096/FASEBJ.9.10.7615159