LDL receptor-related protein: a multiligand receptor for lipoprotein and proteinase catabolism.

摘要: The accumulation of excessive cholesterol-rich lipoproteins within vascular cells, the proliferation and fibrin deposition are hallmark features atherosclerosis. Evidence accumulated over past few years supports hypothesis that one member LDL receptor family, low density lipoprotein receptor-related protein (LRP), affects dynamics each these processes. LRP is expressed in several cell types, including smooth muscle macrophages, also cells atherosclerotic lesions. This a large endocytotic mediates catabolism number molecules known to be important biology, apolipoprotein E- lipase-enriched lipoproteins, thrombospondin, plasminogen activators. capacity mediate may factor development lesion by contributing formation foam cells. has recently been shown mediat...