Anticancer strategies based on the metabolic profile of tumor cells: therapeutic targeting of the Warburg effect.

D. Hadjiolov, Glucose-6-Phosphatase-Aktivität in primären Lebertumoren der Ratte, erzeugt durch hohe Dosen von 4-Dimethylaminazobenzol ,(1969) , 10.1007/BF00524791

Patrick H. Maxwell, Michael S. Wiesener, Gin-Wen Chang, Steven C. Clifford, Emma C. Vaux, Matthew E. Cockman, Charles C. Wykoff, Christopher W. Pugh, Eamonn R. Maher, Peter J. Ratcliffe, The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis Nature. ,vol. 399, pp. 271- 275 ,(1999) , 10.1038/20459

Kavindra Nath, David S. Nelson, Daniel F. Heitjan, Dennis B. Leeper, Rong Zhou, Jerry D. Glickson, Lonidamine Induces Intracellular Tumor Acidification and ATP Depletion in Breast, Prostate and Ovarian Cancer Xenografts and Potentiates Response to Doxorubicin NMR in Biomedicine. ,vol. 28, pp. 281- 290 ,(2015) , 10.1002/NBM.3240

Guo-Qing Chen, Cheng-Fang Tang, Xiao-Ke Shi, Cheng-Yuan Lin, Sarwat Fatima, Xiao-Hua Pan, Da-Jian Yang, Ge Zhang, Ai-Ping Lu, Shu-Hai Lin, Zhao-Xiang Bian, Halofuginone inhibits colorectal cancer growth through suppression of Akt/mTORC1 signaling and glucose metabolism Oncotarget. ,vol. 6, pp. 24148- 24162 ,(2015) , 10.18632/ONCOTARGET.4376

Antonio Cantero, George Weber, Glucose-6-phosphatase activity in normal, pre-cancerous, and neoplastic tissues. Cancer Research. ,vol. 15, pp. 105- 108 ,(1955)

Gloria Bonuccelli, Diana Whitaker-Menezes, Remedios Castello-Cros, Stephanos Pavlides, Richard G. Pestell, Alessandro Fatatis, Agnieszka K. Witkiewicz, Matthew G. Vander Heiden, Gemma Migneco, Barbara Chiavarina, Philippe G. Frank, Franco Capozza, Neal Flomenberg, Ubaldo E. Martinez-Outschoorn, Federica Sotgia, Michael P. Lisanti, The reverse Warburg Effect: Glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts Cell Cycle. ,vol. 9, pp. 1960- 1971 ,(2010) , 10.4161/CC.9.10.11601

Weiwei Yang, Yanhua Zheng, Yan Xia, Haitao Ji, Xiaomin Chen, Fang Guo, Costas A. Lyssiotis, Kenneth Aldape, Lewis C. Cantley, Zhimin Lu, ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect Nature Cell Biology. ,vol. 14, pp. 1295- 1304 ,(2012) , 10.1038/NCB2629

Rebecca C. Osthus, Hyunsuk Shim, Sunkyu Kim, Qing Li, Rahul Reddy, Mita Mukherjee, Yi Xu, Diane Wonsey, Linda A. Lee, Chi V. Dang, Deregulation of Glucose Transporter 1 and Glycolytic Gene Expression by c-Myc Journal of Biological Chemistry. ,vol. 275, pp. 21797- 21800 ,(2000) , 10.1074/JBC.C000023200

Otto Warburg, Über den Stoffwechsel der Carcinomzelle Naturwissenschaften. ,vol. 12, pp. 1131- 1137 ,(1924) , 10.1007/BF01504608

I. Ben-Sahra, J. J. Howell, J. M. Asara, B. D. Manning, Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1 Science. ,vol. 339, pp. 1323- 1328 ,(2013) , 10.1126/SCIENCE.1228792