Lonidamine Induces Intracellular Tumor Acidification and ATP Depletion in Breast, Prostate and Ovarian Cancer Xenografts and Potentiates Response to Doxorubicin

作者: Kavindra Nath , David S. Nelson , Daniel F. Heitjan , Dennis B. Leeper , Rong Zhou

DOI: 10.1002/NBM.3240

关键词:

摘要: … It is most likely that inhibiting MCT-1 is a critical step of acidification due to the fact that the … the expression of MCT-1 in both of the breast cancer cell lines tested, where MCT-1 transports …

参考文章(46)
Oded Ben-Yoseph, John C. Lyons, Chang W. Song, Brian D. Ross, Mechanism of action of lonidamine in the 9L brain tumor model involves inhibition of lactate efflux and intracellular acidification Journal of Neuro-oncology. ,vol. 36, pp. 149- 157 ,(1998) , 10.1023/A:1005819604858
Kavindra Nath, David S. Nelson, Andrew M. Ho, Seung-Cheol Lee, Moses M. Darpolor, Stephen Pickup, Rong Zhou, Daniel F. Heitjan, Dennis B. Leeper, Jerry D. Glickson, (31) P and (1) H MRS of DB-1 melanoma xenografts: lonidamine selectively decreases tumor intracellular pH and energy status and sensitizes tumors to melphalan. NMR in Biomedicine. ,vol. 26, pp. 98- 105 ,(2013) , 10.1002/NBM.2824
Einar K. Rofstad, Paul DeMuth, Robert M. Sutherland, Bruce M. Fenton, 31P nuclear magnetic resonance spectroscopy studies of tumor energy metabolism and its relationship to intracapillary oxyhemoglobin saturation status and tumor hypoxia. Cancer Research. ,vol. 48, pp. 5440- 5446 ,(1988)
Emanuela Scarpi, Marco Montanari, Giovanni Luca Frassineti, Wainer Zoli, Dino Amadori, Francesco Fabbri, Silvia Carloni, Giorgio Cruciani, Ermanno Rondini, Rodolfo Mattioli, Phase II trial of non-pegylated liposomal doxorubicin and low-dose prednisone in second-line chemotherapy for hormone-refractory prostate cancer. Tumori. ,vol. 98, pp. 696- 701 ,(2012) , 10.1700/1217.13491
Alan A. Alfieri, Charles W. Young, Jae Ho Kim, Sang Hie Kim, Potentiation of radiation effects on two murine tumors by lonidamine. Cancer Research. ,vol. 46, pp. 1120- 1123 ,(1986)
Maria Tassini, Gil Navon, Antonio Vivi, Hava Ben-Horin, Ofer Kaplan, Mechanism of Action of the Antineoplastic Drug Lonidamine: 31P and 13C Nuclear Magnetic Resonance Studies Cancer Research. ,vol. 55, pp. 2814- 2821 ,(1995)
Robert J. Canter, Rong Zhou, Susan B. Kesmodel, Yawei Zhang, Daniel F. Heitjan, Jerry D. Glickson, Dennis B. Leeper, Douglas L. Fraker, Metaiodobenzylguanidine and hyperglycemia augment tumor response to isolated limb perfusion in a rodent model of human melanoma. Annals of Surgical Oncology. ,vol. 11, pp. 265- 273 ,(2004) , 10.1245/ASO.2004.05.019
T. Bezabeh, J. L. Evelhoch, P. Thompson, D. J. Sloop, J. J. H. Ackerman, Therapeutic efficacy as predicted by quantitative assessment of murine RIF-1 tumour pH and phosphorous metabolite response during hyperthermia: an in vivo 31P NMR study. International Journal of Hyperthermia. ,vol. 20, pp. 335- 357 ,(2004) , 10.1080/0265673042000196469