Chapter 26 The Immunoendocrine Role of Vitamin D in Autoimmunity
作者： Yoav Arnson , Howard Amital , Yehuda Shoenfeld
DOI: 10.1016/S1571-5078(07)00226-7
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摘要: Publisher Summary This chapter discusses the immuno-endocrine role of vitamin D in autoimmunity. Vitamin has a well-recognized effect on calcium metabolism but it is less acknowledged that this hormone also takes part regulation and differentiation several arms immune system both directly indirectly. direct T- B-cells contributes to molding their responses antigenic stimulation. Th1-cell activation essential for strong cell-mediated responses, including host tumors intracellular pathogens. In autoimmune diseases, Th1 cells are misdirected against self proteins, resulting pathologic conditions such as multiple sclerosis (MS), type 1 diabetes mellitus (DM), inflammatory bowel disease (IBD). Th2 primarily play antibody-mediated immunity seminal response extracellular pathogens generation allergic reactions graft rejection. complex interplay with Th2-mediated cytokines.
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