Hippocampal long-term depression and long-term potentiation encode different aspects of novelty acquisition.

摘要: The hippocampus is required for encoding spatial information. Little known however, about how different attributes of learning are related to types synaptic plasticity. Here, we investigated the association between long-term depression (LTD) and potentiation, both cellular models learning, novelty exploration. We found that exploration a new environment containing unfamiliar objects and/or familiar in locations facilitated LTD, whereas itself, absence objects, impaired LTD. Furthermore, this phenomenon be modulated by 5-hydroxytryptamine 4 receptor activation. In contrast, potentiation was an empty novel environment, but simultaneous object caused depotentiation. also no further LTD could induced. These findings support decisive role acquisition object–place configuration consolidate its candidacy as mechanism.