Temperature-controlled regioselective thiolation of 2-indolylmethanols under aqueous micellar conditions
作者： Shengzhen Zhu , Yu Zhang , Jinyue Luo , Fei Wang , Xiaoji Cao
DOI: 10.1039/C9GC04155A
关键词:
摘要: A sustainable and regioselective synthesis of highly functionalized indole-based sulfides from thiols 2-indolymethanols is described. Notably, this reaction can be performed in the presence 5 mol% In(OTf)3 under aqueous micellar conditions using an inexpensive surfactant DBSA. This protocol offers several advantages including excellent regioselectivities, being organic solvent-free, ease scale-up, broad substrate scope, recycling medium catalyst.
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