Effects of momorcharins on the mouse embryo at the early organogenesis stage
作者： W.Y. Chan , P.P.L. Tam , H.L. Choi , T.B. Ng , H.W. Yeung
DOI: 10.1016/0010-7824(86)90062-4
关键词:
摘要: Previous studies showed that the two forms of momorcharins which are isolated from seeds Momordica charantia L. effective in inducing early and midterm abortions mouse. Momorcharins were found to be teratogenic cultured mouse embryos at organogenesis stage. Morphological abnormalities seen head, trunk limbs. Ultrastructural on visceral yolk sac momorcharin-treated endodermal layer was deranged, membrane invaginations apical surface decreased intercellular space became distended. It is likely action vitro mediated through deleterious effects sac, functions as a vital transport organ for conceptus immediate post-implantation period.
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