Effects of α-trichosanthin and α-momorcharin on the development of peri-implantation mouse embryos

摘要: alpha-Trichosanthin (0.3 mg/25 g) and alpha-momorcharin (0.2 given intraperitoneally to mice on Days 4 6 of pregnancy led an inhibition implantation. In-vitro study the effects these proteins developing mouse embryos showed that did not affect transformation morulae blastocysts but further development was impaired: many failed hatch from zona, incidence successful attachment a plastic substrate decreased extent trophoblastic outgrowth diminished. Inner cell mass less affected than trophoblast. The in-vivo implantation may therefore be consequence deleterious effect