Association between early pregnancy vitamin D status and changes in serum lipid profiles throughout pregnancy

摘要: Abstract Objective To evaluate the associations between first trimester 25-hydroxyvitamin D [25(OH)D] status and changes in high-density lipoprotein cholesterol (HDL-c), low-density (LDL-c), total (TC), triglyceride (TG) concentrations, TG/HDL-c, TC/HDL-c ratios throughout pregnancy. We hypothesized that 25(OH)D inadequacy is associated with lower concentrations of HDL-c higher LDL-c, TC, TG, Methods A prospective cohort study 3 visits at 5–13 (baseline), 20–26, 30–36 gestational weeks, recruited 194 pregnant women attending a public health care center Rio de Janeiro, Brazil. Plasma were measured using liquid chromatography–tandem mass spectrometry. classified as adequate (≥ 75 nmol/L) or inadequate ( Results At baseline, 69% had 25(OH)D. Women mean LDL-c than those (91.3 vs. 97.5 mg/dL; P = 0.064) baseline. HDL-c, TG/HDL-c ratios, increased pregnancy independently (ANOVA for repeated measures P  Conclusions Inadequate plasma during early more pronounced Changes these cardiovascular markers suggest importance ensuring vitamin beginning