CHANGES IN HUMAN NATURAL KILLER ACTIVITY EARLY AND LATE AFTER RENAL TRANSPLANTATION USING CONVENTIONAL IMMUNOSUPPRESSION

摘要: The natural killer (NK) cell activity of human peripheral blood lymphocytes falls following major surgical procedures including renal transplantation but in non-immunosuppressed individuals returns to normal levels within the first 72 hr after operation. In allograft recipients, if this early postoperative fall is excluded from analysis, NK function appears follow changes function, suggesting that vivo, as has been reported vitro, generated during activation alloreactive process. an additional group patients whose grafts were functioning for between 3 and 102 months cadaveric using conventional immunosuppression, was depressed comparison with control subjects. However, some who more than 48 post-transplant had activity. Collectively, these results suggest may recover despite continued administration immunosuppressive agents.