Studies on polyomavirus persistence and polyomavirus-induced tumor development in relation to the immune system

摘要: Publisher Summary Murine polyomavirus is an oncogenic small DNA virus in the Papova group. The was found to induce tumors different tissues of mice, hamsters, and rabbits, hence, name polyoma. chapter reviews recent data for role immune system persistence polyomavirus-induced tumor development. In vivo vitro studies suggest that cellular system, particular T cells, plays a major prevention polyoma development rejection tumors. discusses molecular characteristics polyomavirus. target T-cell-dependent response against cells tumor-specific transplantation antigen (TSTA). Viral factors, host route inoculation influence viral replication, persistence, provides account on immunocompetent immunodeficient mice. summarizes findings regarding infection , including immunologic control Mice with persistent are at risk developing if their T-cell function abrogated. Detailed various ways immunizing or preventing may create new paths also inhibiting