Oncogenic Properties Of The Middle T Antigens Of Polyomaviruses
作者： Friedemann Kiefer , Sara A Courtneidge , Erwin F Wagner , None
DOI: 10.1016/S0065-230X(08)60837-4
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摘要: Publisher Summary This chapter discusses the oncogenic properties of middle T antigens polyomaviruses. Oncogenic viruses provide reagents that are capable transforming cells in a relatively small number defined molecular events. Among viruses, murine polyomavirus is outstanding its ability to cause transformation broad spectrum cell types entirety called “polyomavirus tumor constellation.” Two polyomaviruses have been isolated from their respective hosts, mice, and hamsters. Both display very similar genomic organization consisting circular genome; strands encoding early late gene products transcribed opposite directions noncoding region functions as replication origin well transcriptional control region. Polyomaviruses share this general structure with other papovaviruses. The summarizes biochemical PymT antigen consequences expression vivo. Expression hamster vivo discussed analysis PymT-transformed endothelial provided.
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sci-hub.se 参考文章(67)
D. Metcalf, T. M. Roberts, V. Cherington, A. R. Dunn, The in vitro behavior of hemopoietic cells transformed by polyoma middle T antigen parallels that of primary human myeloid leukemic cells. The EMBO Journal. ,vol. 6, pp. 3703- 3709 ,(1987) , 10.1002/J.1460-2075.1987.TB02704.X
J S Brugge, A Aguzzi, P Soriano, E F Wagner, J E Thomas, Induction of tumor formation and cell transformation by polyoma middle T antigen in the absence of Src. Oncogene. ,vol. 8, pp. 2521- 2529 ,(1993)
R. M. Kypta, A. Hemming, S. A. Courtneidge, Identification and characterization of p59fyn (a src-like protein tyrosine kinase) in normal and polyoma virus transformed cells. The EMBO Journal. ,vol. 7, pp. 3837- 3844 ,(1988) , 10.1002/J.1460-2075.1988.TB03269.X
S. H. Cheng, R. Harvey, P. C. Espino, K. Semba, T. Yamamoto, K. Toyoshima, A. E. Smith, Peptide antibodies to the human c-fyn gene product demonstrate pp59c-fyn is capable of complex formation with the middle-T antigen of polyomavirus. The EMBO Journal. ,vol. 7, pp. 3845- 3855 ,(1988) , 10.1002/J.1460-2075.1988.TB03270.X
Joan Brugge, Origins of human cancer : a comprehensive review Cold Spring Harbor Laboratory Press. ,(1991)
Luis P. Villarreal, Common Mechanisms Of Transformation By Small DNA Tumor Viruses ,(1989)
C. J. Dawe, T. L. Benjamin, K. Ballmer-Hofer, D. A. Talmage, R. Freund, G. Mandel, Variations in polyoma virus genotype in relation to tumor induction in mice. Characterization of wild type strains with widely differing tumor profiles. American Journal of Pathology. ,vol. 127, pp. 243- 261 ,(1987)
G. Superti-Furga, S. Fumagalli, M. Koegl, S.A. Courtneidge, G. Draetta, Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src. The EMBO Journal. ,vol. 12, pp. 2625- 2634 ,(1993) , 10.1002/J.1460-2075.1993.TB05923.X
S. Kaech, J. Muser, C. Moroni, K. Ballmer-Hofer, Stimulation of pp60c-src kinase activity in FDC-P1 cells by polyoma middle-T antigen and hematopoietic growth factors. Oncogene. ,vol. 4, pp. 1433- 1439 ,(1989)
R Lindsay Williams, Sara A Courtneidge, Erwin F Wagner, None, Embryonic lethalities and endothelial tumors in chimeric mice expressing polyoma virus middle T oncogene Cell. ,vol. 52, pp. 121- 131 ,(1988) , 10.1016/0092-8674(88)90536-3