The impact of new technologies on vaccine development.

摘要: The ability to move genetic determinants between species using in vitro gene-manipulation techniques has opened up new approaches vaccine development. This rapidly grown into an exciting area of research both academic and industrial laboratories. There are numerous scientific challenges which require multidisciplinary teams solve problems creating immunogens. challenged our existing knowledge about protein structure conformation, microbial pathogenicity the immune system. Recombinant-DNA invaluable as tools analysis antigen production. surface micro-organisms can also be minutely explored with use synthetic peptides monoclonal antibodies. Nevertheless, these technologies do not allow us circumvent need for detailed understanding pathogens disease process. What is apparent from work carried out so far that there few easy answers development it realistic expect rapid solutions problems. As many potential targets constructing novel vaccines human animal diseases, helpful establish some priorities. a tendency look at effective simply direct producing them more economically or enhanced safety stability. advantage this approach considerable background will have already been establishing basis application recombinant DNA techniques. However, lead conflicts (often within same institute company) old technologies. could detriment still only partly developed may good enough yet compete cost efficacy. ambitious, eventually rewarding, attempt develop where none had existed before. vast untapped market, especially parasitic but much likely necessary. Indeed, most accurately referred basic rather than totally new, way off. Having directed towards specific organism options available strategy adopt. discussed review possible consider subunits, antigens live (attenuated heterologous) organisms vaccines.(ABSTRACT TRUNCATED AT 400 WORDS)