Effect of ampicillin administration on the excretion of twelve oestrogens in pregnancy urine.

摘要: The excretion of twelve oestrogens in urine, pooled daily from a group pregnant women, was determined before, during and after ampicillin administration (2 g/day, for 3 days). On the second day total oestrogen fell to 67% mean control value, oestriol 69% that other eleven individual an average 62% values. In general, on third treatment two post-treatment days this decrease tended be corrected. patterns change urinary levels metabolites provided no clear lead basic mechanism impairment excretion. However, as drug affected all their more or less same way it did oestriol, is possible interferes primarily with enterohepatic circulation mother has been established reasonable certainty case oestriol.