Faecal level of urobilinogen: an indication for the risk of superinfection and of failure of oral anticonception?

作者: E. J. Vollaard , M. M. Jankowiak , N. F. Muller , H. A. L. Clasener

DOI: 10.1007/BF01959465

关键词:

摘要: The influence of clindamycin, dicloxacillin, minocycline and norfloxacin on the faecal concentration urobilinogen was investigated. studied drugs were administered orally in standard dosage for six days to groups volunteers. A decrease following administration clindamycin (P<0.01) dicloxacillin (P<0.05) found. possible predictive value a level as an indicator impairment microbial colonization resistance risk failure oral anticonceptive treatment is discussed. It suggested that should not be combined with unless more specific investigations have excluded interaction these oestrogen metabolism bowel.

参考文章(9)
H. A. L. Clasener, E. J. Vollaard, H. K. F. van Saene, Long-term prophylaxis of infection by selective decontamination in leukopenia and in mechanical ventilation Clinical Infectious Diseases. ,vol. 9, pp. 295- 328 ,(1987) , 10.1093/CLINIDS/9.2.295
H. Adlercreutz, F. Martin, M. J. Tikkanen, M. Pulkkinen, Effect of ampicillin administration on the excretion of twelve oestrogens in pregnancy urine. European Journal of Endocrinology. ,vol. 80, pp. 551- 557 ,(1975) , 10.1530/ACTA.0.0800551
A. Heimdahl, C. E. Nord, Effect of erythromycin and clindamycin on the indigenous human anaerobic flora and new colonization of the gastrointestinal tract European Journal of Clinical Microbiology. ,vol. 1, pp. 38- 48 ,(1982) , 10.1007/BF02014139
H. Saxerholt, B. Carlstedt-Duke, T. Høverstad, E. Lingaas, K. E. Norin, M. Steinbakk, T. Midtvedt, Influence of antibiotics on the faecal excretion of bile pigments in healthy subjects Scandinavian Journal of Gastroenterology. ,vol. 21, pp. 991- 996 ,(1986) , 10.3109/00365528608996410
Henri Saxerholt, Tore Midtvedt, Bengt E. Gustafsson, Deconjugation of bilirubin conjugates and urobilin formation by conventionalized germ-free rats Scandinavian Journal of Clinical & Laboratory Investigation. ,vol. 44, pp. 573- 577 ,(1984) , 10.1080/00365518409083613
Anders Heimdahl, Carl Erik Nord, Influence of Doxycycline on the Normal Human Flora and Colonization of the Oral Cavity and Colon Scandinavian Journal of Infectious Diseases. ,vol. 15, pp. 293- 302 ,(1983) , 10.3109/INF.1983.15.ISSUE-3.10
E. J. Vollaard, H. A. L. Clasener, A. J. A. van Griethuysen, A. J. H. M. Janssen, A. H. J. Sanders-Reijmers, N. F. Muller, P. J. C. Huige, Influence of cefaclor, phenethicillin, co-trimoxazole and doxycycine on colonization resistance in healthy volunteers Journal of Antimicrobial Chemotherapy. ,vol. 22, pp. 747- 758 ,(1988) , 10.1093/JAC/22.5.747
E. J. Vollaard, H. A. L. Clasener, A. J. A. van Griethuysen, A. J. Janssen, A. J. Sanders-Reijmers, Influence of amoxycillin, erythromycin and roxithromycin on colonization resistance and on appearance of secondary colonization in healthy volunteers Journal of Antimicrobial Chemotherapy. ,vol. 20, pp. 131- 138 ,(1987) , 10.1093/JAC/20.SUPPL_B.131
Midtvedt T, Effects of antimicrobial agents upon the functional part of the intestinal flora. Scandinavian Journal of Infectious Diseases. ,vol. 49, pp. 85- ,(1986)