Metipranolol and propranolol: No CNS effects of a single oral dose

摘要: Effects of single oral doses the β-blocking drugs propranolol (40 mg) and metipranolol (Disorat, Boehringer, Mannheim, FRG, 5 20 mg), in comparison with placebo, on mental performance psychophysiological measures were investigated a double-blind crossover study comprising 12 healthy volunteers. evaluated using battery highly reliable sensitive computerized indices comprehensive range measures. Propranolol had no effects performance, contrast to findings previous for bunitrolol (Stresson, Ingelheim, FRG). There marked some autonomic functions; dose-dependent heart rate response, dose-independent blood pressure finger tremor. In effect tremor less rate. The lack psychotropic as compared cannot be predicted from pharmacokinetic properties or peripheral three drugs, arguing need systematic screening psychometric methods current new drugs. A between given dose repeated administration suggested that differences profile acute chronic drug are small.