Hemodynamic consequences of neuropeptide Y-induced obesity.

摘要: Abstract Background Acute central nervous system administration of neuropeptide Y (NPY) elicits variable hemodynamic responses. Chronic intracerebroventricular (ICV) NPY produces obesity in rats. Obesity has been shown to increase arterial pressure. Methods In this study we examined the chronic effects NPY-induced obesity. Sprague-Dawley rats were implanted with radiotelemetry transmitters continuously record heart rate and pressure conscious state. Neuropeptide or vehicle was delivered into third cerebral ventricle by osmotic minipumps over 2 weeks. Three groups studied: vehicle, NPY-treated (free-fed), (pair-fed vehicle-treated rats). Results increased food intake body weight free-fed animals, substantially augmented visceral adiposity both free- pair-fed Despite adiposity, ICV unstressed did not decreased rate, suggesting a sympathoinhibitory effect. Conclusions induced 2-week does pressure, perhaps indicating inhibition sympathetic outflow that may oppose pressor effect adiposity.