Hypertension and sympathetic hyperactivity induced in rats by high-fat or glucose diets.

摘要: Male Sprague-Dawley rats fed either a high-fat diet or glucose-enriched developed higher blood pressure (BP) than control diet. After 8 wk of treatment systolic BP was 11% (P less 0.01) in fat-fed and 7% 0.05) glucose-fed when compared with the Rats hypertension only they were allowed to overeat become obese hyperinsulinemic. But their feeding restricted prevent obesity hyperinsulinemia, remained normotensive. In contrast, elevated consuming glucose absence hyperinsulinemia. 7 treatment, urinary norepinephrine excretion 1.9 +/- 0.1, 1.5 0.1 micrograms/day high-fat, glucose, diets, respectively 0.05 vs. control). Higher hypertensive suggests that increased sympathetic nervous system (SNS) activity might participate mediating effects dietary fat on BP. addition, insulin may contribute raising diet, directly indirectly through its stimulatory effect SNS. We conclude chronic diets high increases enhances SNS rats.