The Alliance of Animal Models in Biomedical Investigations

摘要: Animal experiments have led to the development of new knowledge and discoveries ranging from vaccines, antibodies, antibiotics, immunosuppressives, organ transplantation minimally invasive surgeries diagnostic methods. There are multiple animal models described in literature classified accordingly based on how model has been characterized they adoptable study certain diseases. These include spontaneous disease that naturally express which may be analogous a human disease. The experimental those or phenotype is induced experimentally through manipulating environment, diet, by introducing chemicals immunological agents resulting physiological pathological changes mimic Genetically-engineered modification mutation DNA germline cells becomes heritable at fore front research today. They serve purpose identifying molecular genetic pathways many None these ideal models, but represent potential reveal pathological, mechanisms for particular An important consideration minimizing use search alternate could replaced vitro methods computer simulations can reliably predict same endpoints. Society constantly demanding minimal animals research. Scientists accepted this challenge implementing less painful procedures. considering lower organisms validating methodologies simulations. Despite successes, even today diseases lack validated thereby hampering translational progress. It anticipated will developed as we gain better understanding into