ESR1 single nucleotide polymorphism rs1062577 (c.*3804T>A) alters the susceptibility of breast cancer risk in Iranian population.
作者： Zahra Dehghan , Samira Sadeghi , Hossein Tabatabaeian , Kamran Ghaedi , Mansoureh Azadeh
DOI: 10.1016/J.GENE.2017.02.016
关键词:
摘要: Abstract Objectives Albeit single nucleotide polymorphisms related to ESR1 gene have been studied, only a number of them reported be associated with breast cancer risk. rs1062577 is one the most recent microRNA-related SNPs; however, no study has conducted investigate significance this polymorphism in Iranian population. In study, we aimed frequency and also association between cancer. Materials methods position was genotyped by Tetra-primer ARMS-PCR totally 182 blood specimens obtained from patients (n = 86), healthy donors (n = 96). The distribution different genotypes statistically analyzed terms potential alleles, risk clinicopathological criteria patients. Results statistical analyses confidently indicated that A allele increased both univariate multivariate regression models (Odds Ratio = 8.403 32.602 respectively). T stage I (p-value = 0.025). silico studies implied can alter binding capacity mRNA miRNAs via either breakage or formation hydrogen bonds. Conclusion significantly dramatically elevated greater stages
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