Case-Cohort Analysis of Agricultural Pesticide Applications near Maternal Residence and Selected Causes of Fetal Death

摘要: The potential association between fetal death and residential proximity to agricultural pesticide applications was examined in 10 California counties for 1984. A case-cohort analysis utilized 319 cases of selected causes other than congenital anomalies 611 non-cases. statewide database all restricted pesticides linked maternal address; within 1 mile (1.6 km) provided a surrogate daily exposure. Pesticides were grouped by chemical class mechanism acetylcholinesterase inhibition. Multivariate proportional hazards models using time-dependent exposure variables fit each grouping. Overall, showed no strong with death. Slightly elevated risks observed women who resided near halogenated hydrocarbons, carbamates, estrogenic pesticides, carbamate inhibitors during the second trimester, hazard ratios 1.3 (95% confidence interval (CI): 1.0, 1.8), CI: 1.4 0.8, 2.5), respectively. In month-by-month analysis, when occurred gestational months 3 4 carbamates 5 hydrocarbons. Since previous studies have relied on personal recall exposure, major strengths this study objective source environmental assessment use data timing