Additional ST-segment elevation during thrombolytic therapy in patients with acute ST-elevation myocardial infarction: Impact on myocardial salvage and final infarct size

摘要: The aim of the study was to investigate clinical significance additional ST-segment elevation that occurs during thrombolytic therapy. Therefore, we classified 153 patients with a first acute myocardial infarction (MI) into two groups: Group A, 55 >-1 mm above initial ST therapy and B, 98 patient without this electrocardiographic pattern. Among anterior MI, A (n=33) had no reduction from ST-predicted final QRS-estimated infarct size (+12% versus −27%; p=0.0005) larger (QRS-score; 18% 12%: p=0.0002) than B (n=41). inferior (n=22) smaller (−30% −53%; p=0.03) 15% 9%; (n=57). area under curve (AUC) CK CK-MB higher in compared those (anterior MI: AUC-CK: 22048 19490 U.h.I−1; p=0.07; AUC-MB: 2227 2016 U.h.l−1; p=0.11; 17206 11004 U.h.l.−1; p=0.01; 2193 1046 p-0.007). Both global left ventricular function resolution were significantly better B. Two three vessel disease observed more frequently A. Additional suggests reduced salvage by thus may result size.