Repeated stress and structural plasticity in the brain.

摘要: Although adrenal steroid receptors are distributed widely throughout the central nervous system, specific limbic and cortical regions targeted by stress hormones play a key role in integrating behavioral physiological responses during adaptation to subsequent stressors. When stressor is of sufficient magnitude or prolonged, it may result abnormal changes brain plasticity that, paradoxically, impair ability appropriately regulate respond Here we review how repeated produces alterations animal models, discuss its relevance associated with these regions. Interestingly, prolonged opposing effects on structural plasticity, notably dendritic atrophy excitatory synapse loss hippocampus prefrontal cortex, growth dendrites spines amygdala. The granule cells dentate gyrus also significantly affected through decrease rate neurogenesis following stress. How functional impairments stress-related mental illnesses discussed this context. Finally, cumulative impact stress-induced aging.