Fluoxetine increases extracellular dopamine in the prefrontal cortex by a mechanism not dependent on serotonin : A comparison with citalopram
作者： Laura Pozzi , Roberto Invernizzi , Claudio Garavaglia , Rosario Samanin
DOI: 10.1046/J.1471-4159.1999.0731051.X
关键词:
摘要: Abstract : Fluoxetine at 10 and 25 mg/kg increased (167 205%, respectively) the extracellular dopamine concentration in prefrontal cortex, whereas (but not 10) citalopram raised (216%) dialysate dopamine. No compound modified nucleus accumbens. The effect of both compounds on cortical was significantly affected by 300 p-chlorophenylalanine (PCPA) (fluoxetine, saline, 235% ; PCPA, 230% citalopram, 179% 181%). PCPA depleted tissue serotonin ~90 50%, respectively, prevented fluoxetine 246% 110% 155% 96%). Citalopram from 0.1 to 100 μM (251-520%), only (143-231%). similarly (98-336%) (117-318%). significnatly reduced basal effects (saline, 272% 203%) 345% 258%) but did modify their 220% 202% 191% 211%). results clearly show that high concentrations do depend serotonin.
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